Any body knows what difference between B6243 "Cylinder Mode" & "Engine Mode"

Any body knows what difference between B6243 "Cylinder Mode" & "Engine Mode" ?
trying to put LS1 knock sensors to the side of block in LS3 conversion

thanks in advance

Cylinder Mode: PCM determines misfires per cylinder.
Engine Mode: PCM determines misfires per knock sensor (i.e. 4 cylinders grouped together).

Thanks Joe