I haven't contributed to this thread until now because joecar has been giving you good guidance, but I'd like to give you my view on where you're at now. The engine specs you posted in your original post are not good specs for a street driven vehicle. It's not going to be an easy engine to tune. I personally prefer running closed loop where possible (especially in areas where ethanol blending is mandatory), but it may be very challenging with your build. If you have to run open loop, then run it a bit on the rich side to ensure good fueling with changing ethanol content. People have differing opinions on the MAF... personally, I think that the MAF sensor is one of the best things that GM ever put into their vehicles. Don't be in too much of a hurry to remove that sensor... in some circumstances, it can be used as a diagnostic tool.
Finally... I think that your cam is too big for street use. I think that your compression is too high for your cam. I think that you're going to have some bucking at cruising speeds and I think you're going to have hours of fun trying to tune this beast. Enjoy!