Andrew,
The PLX or any WBO2 operates completely independent from any engine control electronics. Unless you are placing the WBO2 sensor in the bung normally intended for the factory NBO2 and using the emulated NBO2 output from the WBO2 controller as my drawing depicted; the only connection to the vehicle's electronics is via a cigarette lighter socket or the like for 12 Volt DC power. It's just like any other 12 V accessory that you might run off your vehicle electrical system like a CD Changer or something similar.
I initially had two extra bungs welded into my exhaust system (a left and a right) and took the bung plugs in along with some anti-seize compound to put on the threads. The guy who welded them in did an excellent welding job but he wouldn't let me stay there in the shop claiming insurance restrictions (which is probably true). Anyway, I asked him to apply the anti-seize liberally and he said to keep mine because he had some there in the shop and off I went into the customer waiting room. Afterwards, he told me that he just put the plugs in snug, but not tight. Well, the next day I crawled under my truck and tried to remove first one, then the other plug to no avail. They were stuck solid with no evidence of anti-seize. I went back to the shop and told them of my dilemma. Several of the muffler technicians tried to get them loose, heating them with a torch and cursing madly. Then they said that they were just stuck for good and welded in another bung on the left side and put my WBO2 sensor in. This time, I brushed on the anti-seize. Sorry for the rant, but I'm still upset and this was three months ago.
Anyway, by watching the outputs from the two NBO2 sensors and the injector duty cycles, etc, everything is balanced and I'm really not concerned about monitoring the left versus the right.
All my best,
Steve
PS
One other thing. I was really tempted to buy the M-250 and I'm so glad that I didn't. It turns out that I watch the M-300 a lot, traffic permitting because I'm keenly aware of the fact that I'm trying to tune the beast to it's optimum.